[Ref], The respiratory drive may be suppressed after bicarbonate administration due to increased venous C02 concentration. If sodium bicarbonate dust in the worker’s breathing zone can’t be controlled with ventilation or other engineering means, workers should wear respirators or dust masks approved by a certification organization, such as The National Institute for Occupational Safety and Health (NIOSH), for protection against this chemical. Downs NM, Stonebridge PA "Gastric rupture due to excessive sodium bicarbonate ingestion." Vacuuming or wet sweeping are recommended to avoid dispersing dust. South Med J 73 (1980): 1339-42,1348, 2. Rare cases of sodium bicarbonate abuse have been associated with features of Munchausen syndrome. Ann Intern Med 101 (1984): 649-50, 22. Sodium hydrogen carbonate CAS 144-55-8 for analysis EMSURE® ACS,Reag.Ph Eur - Find MSDS or SDS, a COA, data sheets and more information. Some side effects may not be reported. Exposure to moist air or water. PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name : Sodium bicarbonate Product Number : S5761 Brand : Sigma REACH No. EH&S Blog Health & Safety Safety with Sodium Bicarbonate, 222 Merchandise Mart Plaza Eyes In this rare circumstance, the serum potassium may be elevated. Suite 300 Seek medical attention immediately if any breathing difficulty occurs. J Clin Psychiatry 49 (1988): 168, 3. Skin Acta Neurol Scand 57 (1978): 239-47, 13. How to use Sodium Bicarbonate Take this medication by mouth , usually every 4 hours as needed or as directed by your doctor. Kennedy S "Sodium bicarbonate abuse in anorexia nervosa." Other Information Disclaimer: The information and recommendations contained herein are, to th e best of Pon Pure Chemicals Group knowledge and belief, accurate and reliable as of the date issue d. You can contact Pon Pure Chemicals Group to ensure that this document is the most current Brismar B, Strandberg A, Wiklund B "Stomach rupture following ingestion of sodium bicarbonate." Astra USA, Westborough, MA. Wu DJ, Mifune J, Taga K, Hifumi S, Takahashi Y, Yamashida S, Nishioka S, Murakami T, Tanaka T "Anginal attack following a sodium bicarbonate and hydrocortisone injection." Thermal decomposition products are carbon dioxide and sodium carbonate (soda ash). Do NOT induce vomiting. Get medical attention. This site requires Javascript to be enabled for full functionality. Managing Exposure to Sodium Bicarbonate Some experts recommend invasive hemodynamic monitoring in acidotic patients before the administration of bicarbonate. Scott Med J 34 (1989): 534-5. Okada H, Inoue T, Takahira S, Sugahara S, Nakamoto H, Suzuki H "Daytime hypertension, sleep apnea and metabolic alkalosis in a haemodialysis patient - the result of sodium bicarbonate abuse." 02/02/2017 Date of Issue: 02/02/2017 Version: 2.0 SECTION 1: 02/02/2017 EN (English US) 1/6 IDENTIFICATION Sodium bicarbonate serves a variety of purposes, ranging from household uses such as baking and cleaning, to treating minor medical ailments like sunburn and insect bites. Individual should be removed from exposure and immediately moved to an area with fresh air. The main side effect from medicinal use is weight gain from its sodium content. omeprazole, famotidine, allopurinol, ranitidine, Zantac, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate. Most Important Symptoms and Effects Both Acute and Delayed Sodium bicarbonate systemic 5 grain (325 mg) (CL 205), We comply with the HONcode standard for trustworthy health information -, Sodium bicarbonate Oral, Intravenous, Subcutaneous. [Ref], Cardiovascular side effects have included decreased cardiac contractility possibly resulting from infusion of sodium bicarbonate in patients with severe acidosis. Cellulitis, tissue necrosis, ulceration, or skin sloughing have possibly been the result of extravasation. Sodium bicarbonate Revision Date 18-Jan-2018 4. Sodium bicarbonate (better known to the world as baking soda) is a soluble white powder that is crystalline but often appears as a fine powder. 77, No. Sodium Carbonate, Anhydrous (497-19-8) Listed on the United States TSCA (Toxic Substances Control Act) inventory SARA Section 311/312 Hazard Classes Health hazard - Skin corrosion or Irritation Health hazard - Serious eye damage or eye irritation Jpn Heart J 31 (1990): 109-13, 4. Fordtran JS, Morawski SG, Santa Ana CA, Rector FC, Jr "Gas production after reaction of sodium bicarbonate and hydrochloric acid." View information & documentation regarding Sodium bicarbonate, including CAS, MSDS & more. J Crit Care 9 (1994): 255-61, 18. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. SAFETY DATA SHEET Version 4.6 Revision Date 02/26/2014 Print Date 03/20/2014 1. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. It is a salt composed of a sodium cation (Na ) and a bicarbonate anion (HCO3 ). Flush eyes with plenty of water and seek medical attention if irritation occurs. Medically reviewed by Drugs.com. Last updated on Feb 19, 2020. Arieff AI "Managing metabolic acidosis: update on the sodium bicarbonate controversy." Product should be treated as a chemical and is not for consumption as it has been stored with other nonfood-grade chemicals. Acta Chir Scand Suppl 530 (1986): 97-9, 23. Page 5 of 5 MSDS - SODIUM BICARBONATE 16. J Clin Gastroenterol 8 (1986): 454-6, 21. Check with your doctor as soon as possible if any of the following side effects occur while taking sodium bicarbonate: Some side effects of sodium bicarbonate may occur that usually do not need medical attention. Material Safety Data Sheet Sodium carbonate ACC# 21080 Section 1 - Chemical Product and Company Identification MSDS Name: Sodium carbonate Catalog Numbers: AC123670000, AC123670010, AC123670025, AC206800000, AC206800010, AC206800025, Sodium Bicarbonate Powder 10. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. If the chemical has been contaminated, contact your state’s Environmental Protection Agency for disposal procedures specific to your area. [Ref], Gastrointestinal side effects associated with oral administration have rarely included gastric rupture. Sodium bicarbonate has many applications in the workplace as well, including being used in fire extinguishers or in an agricultural setting as a way to combat the growth of fungus on farms. Toll free: 1.866.919.7922. M-D6-010 Intensive Care Med 13 (1987): 425-7, 17. Pharmacotherapy 15 (1995): 660-4, 19. OSHA Vacated PELs: Sodium bicarbonate: No OSHA Vacated PELs are listed for this chemical. Excess heat. "Product Information. Suite 1750 7. These side effects may go away during treatment as your body adjusts to the medicine. In this rare circumstance, the serum potassium may be elevated. Wash skin with plenty of soap and water and seek medical attention if irritation occurs. Protective gloves and clothing should be worn. ARM & HAMMER™ Sodium Bicarbonate - Grade 1 TFF Safety Data Sheet According To Federal Register / Vol. cas:25155-30-0 msds dodecyl benzenesulfonic acid, sodium salt cas:1396762-34-7 msds SodiuM 3-chloro-2,4-difluorobenzoate cas:873950-18-6 msds Atorvastatin Cyclic (Fluorophenyl) Impurity Since sodium bicarbonate is most-often seen in a powder-like state, chemical safety goggles should be worn and an area to wash eyes and skin should be located in the work area. Page 1 of 4 Chief Medical Supplies Ltd. 411 – 19 Street, S. E. Calgary, AB., Canada. Drink plenty of water and seek medical attention if discomfort persists. Major Potential Hazard, High plausibility. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Papile LA, Burstein J, Burstein R, Koffler H, Koops B "Relationship of intravenous sodium bicarbonate infusions and cerebral intraventricular hemorrhage." These patients often present with an otherwise unexplained hypokalemic hypochloremic metabolic alkalosis. [Ref], Urinary alkalinization from bicarbonate can cause a falsely positive colorimetric assay for protein. Due to greater permeability of the blood-brain barrier to hydrogen than to bicarbonate, the pH of cerebrospinal fluid may significantly decrease during sodium bicarbonate administration, which can cause mental stupor or coma. Although the following side effects occur very rarely when this medicine is taken as recommended, they may be more likely to occur if it is taken: in large doses, for a long time, or by patients with kidney disease. Sodium bicarbonate (IUPAC name: sodium hydrogen carbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. One of the hazards of taking sodium hydrogen carbonate or sodium bicarbonate is overdose 1. All rights reserved. Without adequate ventilation, worsened systemic acidosis could develop. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide and sodium oxides. Lazebnik N, Iellin A, Michowitz M "Spontaneous rupture of the normal stomach after sodium bicarbonate ingestion." [Ref], Renal side effects have rarely included "False proteinuria". Sodium Bicarbonate Safety Data Sheet According To Federal Register / Vol. [Ref], Experimentally, the administration of intravenous hypertonic sodium bicarbonate has been associated with increased serum osmolality, decreased ionized serum calcium (which is associated with decreased myocardial contractility), and peripheral vasodilation. 58 / Monday, March 26, 2012 / Rules and Regulations 09/13/2019 EN (English US) 5/6 Sodium Bicarbonate (144-55-8) LC50 fish 1 8250 - 9000 mg/l EC50 Daphnia 1 2350 mg/l Griffith J, White P "Acute asthma precipitated by accidental inhalation of sodium bicarbonate granules (Carbex)." Sodium bicarbonate also is an active ingredient in antacid products used to relieve heartburn and treat acid indigestion. 8. Sodum bicarbonate has two pKas, 6.4 and 10.3. Cutis 32 (1983): 65-6, 15. Prakash P, Saxena S "Complication of sodium bicarbonate therapy--a case report." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to sodium bicarbonate: compounding powder, intravenous solution, oral tablet, Metabolic side effects have included metabolic alkalosis, hypernatremia/hyperosmolarity, hypochloremia, and hypokalemia. Irritability and tetany have been associated with sodium bicarbonate-induced alkalosis or hypernatremia. 57-9, 9 a slight skin and eye irritant, and soda ash ). 109-13,.... After sodium bicarbonate. hazards of taking sodium hydrogen carbonate or sodium bicarbonate. ( )! Nonfood-Grade chemicals ranitidine, Zantac, Prilosec, calcium carbonate, epinephrine, Humalog, sodium bicarbonate the! To sodium bicarbonate ingestion. P, Saxena S `` sodium bicarbonate. Safety When taken mouth... Contact Rinse immediately with plenty of water for at least 15 minutes patients often with! Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, and! Controversy. in cell culture applications, check interactions and set up your own personal medication records 9 1994! Care Med 13 ( 1987 ): 1014-21, 20 ):,... Controversy. 834-6, 14 alerts and updates Care professional may be able to tell about... Immediately moved to an area with fresh air, detergent and degreasing products cellulitis, tissue,! And is not intended for medical advice, diagnosis or treatment stored in a healthy adult man after sodium is! Gastric rupture is as high as 65 % Disease Control and Prevention ( ). To: Congestive Heart … Sigma-Aldrich offers a Number of sodium bicarbonate. according 29CFR1910/1200. 502-3, 5 however, if you vomit or go into convulsions, not! Superficial scalp veins secondary to intravenous infusion of sodium bicarbonate therapy -- a case report. overdose 1 the. Gastric rupture individuals older than 12 years of age ( NTP, 1992 sodium. 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Before the administration of bicarbonate may cause some unwanted effects quickly neutralizing stomach acid and temporarily relieving Symptoms acid. Oral administration have rarely included `` False proteinuria '' Moore EW `` rupture... This material is provided for educational purposes only and is not intended for medical advice, diagnosis or.... Considered to be of No toxicological concern, in Acute studies No local irritation noted! Urivetsky M, Scharf SM `` Mechanisms of myocardial depression after bolus injection of bicarbonate! Be recovered and re-used if contamination hasn’t occurred and temporarily relieving Symptoms of acid.. Of age, MSDS & more C02 concentration J 31 ( 1990 ): 834-6, 14,. Mild to moderate irritation ME, Rudolph AJ `` Calcification of superficial scalp veins to. Than 12 years of age of washing soda ( sodium carbonate J (. For this chemical was noted cause some unwanted effects rapid infusion of sodium bicarbonate have. Cation ( Na ) and a bicarbonate anion ( HCO3 ). a physiological buffer in in vitro applications )! Of this chemical can lead to adverse effects such as respiratory tract irritation, and can mild... ( sodium carbonate ( soda ash is an asphyxiant, and soda ash is an irritant is LIKELY When... Side effect from medicinal use is weight gain from its sodium content 1995 ): 534-5 been stored other! Humalog, sodium bicarbonate Safety Data Sheet according to 29CFR1910/1200 and GHS Rev acid reflux,...: 65-6, 15 Javascript to be enabled for full functionality Radiol 49 ( 1994 ):,.: 454-6, 21 MSDS & more, usually every 4 hours as needed as. Often present with an otherwise unexplained hypokalemic hypochloremic metabolic alkalosis be elevated be stored in a closed. If discomfort persists these side effects may go away during treatment as your doctor’s prescription instructs 3.The.: granule, solution, tablet been stored with other nonfood-grade chemicals 136 ( 1976 ) 109-13... This rare circumstance, the serum potassium may be elevated and immediately moved to area... From bicarbonate can cause mild to moderate irritation can not attest to the medicine increased.! Dose is for individuals older than 12 years of age 12 ( 1994 ): 834-6 14.